5-HYDROXY ISATIN
- Product Name
- 5-HYDROXY ISATIN
- CAS No.
- 116569-09-6
- Chemical Name
- 5-HYDROXY ISATIN
- Synonyms
- 5-HYDROXY ISATIN;Flumazenil Impurity 17;5-hydroxyindoline-2,3-dione;5-Hydroxy-1H-indole-2,3-dione;1H-Indole-2,3-dione, 5-hydroxy-;5-hydroxy-2,3-dihydro-1H-indole-2,3-dione;5-Hydroxy isatin 5-Hydroxy indole-2,3-dione
- CBNumber
- CB72455151
- Molecular Formula
- C8H5NO3
- Formula Weight
- 163.13
- MOL File
- 116569-09-6.mol
5-HYDROXY ISATIN Property
- storage temp.
- -20°C
- solubility
- DMF: 3 mg/ml,DMSO: 5 mg/ml,Ethanol: insol,PBS (pH 7.2): insol
- form
- A solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 6895CR
- Product name
- 5-Hydroxyindoline-2,3-dione
- Packaging
- 2mg
- Price
- $218
- Updated
- 2021/12/16
- Product number
- 6895CR
- Product name
- 5-Hydroxyindoline-2,3-dione
- Packaging
- 25mg
- Price
- $334
- Updated
- 2021/12/16
- Product number
- CHM0386196
- Product name
- 5-HYDROXYISATIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.32
- Updated
- 2021/12/16
- Product number
- 6895CR
- Product name
- 5-Hydroxyindoline-2,3-dione
- Packaging
- 2.5g
- Price
- $2895
- Updated
- 2021/12/16
5-HYDROXY ISATIN Chemical Properties,Usage,Production
Biological Activity
5-hydroxy Isatin is an inhibitor of monoamine oxidase A (MAO-A; IC50 = 8.4 μM).1 It is selective for MAO-A over MAO-B (IC50 = >100 μM). 5-hydroxy Isatin (50 μM) also inhibits atrial natriuretic peptide-induced activation of particulate guanylyl cyclase in rat brain and heart membranes.2
References
1.Medvedev, A.E., Goodwin, B., Chow, A., et al.Inhibitory potency of some isatin analogues on human monoamine oxidase A and BBiochem. Pharmacol.44(3)590-592(1992) 2.Medvedev, A.E., Goodwin, B.L., Sandler, M., et al.Efficacy of isatin analogues as antagonists of rat brain and heart atrial natriuretic peptide receptors coupled to particulate guanylyl cyclaseBiochem. Pharmacol.57(8)913-915(1999)